News from the Molnar-Institute

31.07.2008 DryLab + PeakMatch Workshop in Berlin

For the 31^st of July We are planning a DryLab–user workshop with the title “Computerized design of robust separations in HPLC”

with lively discussions, especially about the future of automated HPLC method development, design space, quality by design, new FDA regulations, etc.

Berlin is an interesting and popular city and has a lot to offer also besides of our program. This could be the ideal occasion to get to know the rejuvenated capital of the new Germany better.
Contributions are welcome. Abstracts should be submitted before the 30^th June 2008

Participation fee:

Registration until 25.07.2008:  € 325,- + VAT, incl. Lunch + Dinner

Registration:            info@molnar-institut.com

Location:                   Hotel Maritim proArte, Friedrichstr. 151 , 10117 Berlin

eMail:                        info.res@maritim.de

Change in the ownership of DryLab® and other Rheodyne® LLC software products
The Molnar-Institute has acquired the complete software program of Rheodyne LLC of the IDEXCorporation in October, 2006. The well known software products, DryLab®, MethodMatch® and ColumnMatch®, originally developed by LCResources Inc., will be maintained, further developed and sold worldwide from the Molnar-Institute, located in Berlin, Germany. Present and future DryLab users will receive software support directly from the Molnar-Institute and from their worldwide DryLab® dealers.

Together with the software program PeakMatch®, which was developed in Berlin at the Molnar-Institute, the company offers now a complete HPLC method development package for the quality control and quality assurance departments in the pharmaceutical, chemical and food-technical industries. The package contains new tools, which are now available for the user for establishing and describing HPLC and UPLC method quality, robustness, and transferability. In this way, important new contributions can be performed for increasing the product quality in the above mentioned industries.

The next DryLab^®-Version 3.9 is now available.
The new mode tG vs. Ternary eluent composition of Eluent B (ACN:MeOH) was developed
("Retention modeling in ternary solvent gradient elution reversed phase chromatography using 30 mm columns" Melvin R. Euerby, Federico Scannapieco, H.J.Rieger, I.Molnar, J.Chromatogr. A 2006, 1121 219-227.)(pdf)

The next PeakMatch^®-Version 3.4 is now available.
The aim of a systematic and automatic collection of all runs and data describing a method and to combine them with a DryLab®-model has been developed further. Now all relevant data of an HPLC-method incl. the original chromatograms and the DryLab model, are stored in a single file and are available to the user for calculating automated gradients and robustness data. New features are:
-Automatic generation of a tG/T-DryLab-model on an Agilent 1100 (ChemStation): The runs are defined and started by PeakMatch®, resulting chromatograms and peak tables are automatically imported and merged correctly. Errors due to an incorrect import of data can thus be avoided.
-The Column-database ColumnMatch® was integrated in PeakMatch®. It contains ca. 300 different RP-Columns, divided in the classes A (acidic), B (basic) and EP (embedded polar) phases. The user can search for 10 different columns with the most similar selectivity in comparison to the reference column.

Courses: The next english DryLab® + PeakMatch® - HPLC user course will take place on 11.- 12.11.2008 in Berlin.

The Molnar-Institute exhibited at the Analytica 2008, 01.04.- 04.04.2008 in Munich/Germany. www.analytica.de

Waters Automated Method Development System (Waters-AMDS) uses DryLab® for the rapid development of robust HPLC-methods

Presentation: The Molnar institute was invited to the conference "Applica", which was organized by the analytic-chemical department of the Swiss Chemical Society on the 8.-9. Nov. 2006 in Olten, Switzerland.
Lecture "Computerized Design of Robust Separations in HPLC with DryLab® und PeakMatch®

Award: The Hungarian Society for Separation Sciences presented the "Csaba Horváth Memorial Award" to Dr.I.Molnar in recognition of his significant contributions to the development of Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC). The Solvophobic Theory of RP-HPLC, developed by Cs.Horvath, W.Melander and I.Molnar has presently over 1800 citations.
www.analytik.de/inhalte/molnar/csaba-horvath-award.htm

Robust HPLC- Methods

Year	Month	Date	City	Language
2008	September	11.- 12.	Berlin	German
2008	November	13.- 14.	Berlin	English

DryLab® + PeakMatch® -user course for HPLC

Year	Month	Date	City	Language
2008	September	09.- 10.	Berlin	German
2008	November	11.- 12.	Berlin	English

HPLC has a number of choices to change a separation: the eluent pH, the temperature, the gradient time and form, ternary eluent composition, buffer- or additive concentration. To evaluate these influences, a set of different experiments have to be performed.
The peak tracking process in such a set of HPLC chromatograms is a difficult and sometimes confusing process, where our eyes have to spring to 8 or more different locations of retention times and of peak areas. PeakMatch®, in combination with DryLab® is an effective and powerful tool for helping to prepare a well tracked data table prior to model the separation selectivity.

Sofar PeakMatch® and DryLab® serve an improved data preparation, data entry and documentation of input runs for DryLab®-models; it supports the optimization of the gradient time tG, %B, temperature and pH as well as their combinations with 2 parameters each.

Advantages are the comfortable import and concurrent treatment of 2 - 6 basic runs for a systematic HPLC method development process. PeakMatch® func-tions can be performed at the same time in all chromatograms and in all peak tables. At the same time input data are shown transparent and can be judged in their chromatographic quality.

last update14.04.2008