Here are the new Features:

The following components were added to the DryLab software package for the first time:

We all know that the "small stuff" is what makes or breaks a chromatography method. The trick is to keep the small stuff under control. DryLab models chromatography variables in seconds - and that power lets you evaluate a much wider range of experimental conditions than would ever be practical in the laboratory. With DryLab you can quickly determine the effects on your separation of pH, temperature, buffer concentration, and much, much more.

Take a look at just some of the features DryLab had to offer:

Temperature/gradient time mode.

We are in the process of adding new modes to DryLab, that allow you to optimize two parameters at a time. The first such mode is temperature vs. gradient mode. It requires you to make four initial runs at two different gradient times and two different temperatures. Look at the example files for the new mode by loading any of the files that start with 3D_. The easiest way to set up your runs is to switch to the right mode and click the clear button at the bottom of data entry. A dialog box will ask you for the two gradient times and temperatures.

You will notice that the resolution map and resolution table are changed for this mode. You can set the current temperature and gradient time by clicking on the value you want. If you want to change the colors of the resolution map click on the color key to get the color control panel. We have provided a number of color combinations to experiment with; they can be loaded with the Open button in the color control panel.

Use more runs to improve predictions:

For all modes (except tG/temp. mode) you can use up to 16 input runs in the data entry table. This means, that if you do additional experiments, you can add the results of those experiments to the data entry section in order to improve DryLab predictions. The number of runs, that are listed in the mode menu, are the minimum number of runs for that mode.

Plate numbers and tailing factors:

DryLab now allows you to enter plate numbers and asymmetry factors for each peak for each run. If your data system provides this information, DryLab will give better peak shape and peak width predictions, if these values are entered. If you only enter these values for one run, DryLab uses that value for all the runs. If you enter the experimentally determined values for each input run, the program will interpolate plate numbers and tailing factors between runs. You can turn the plate number and assymmetry factor columns on and off with the options menu in data entry.

Combine incomplete runs to build the DryLab model:

Starting with DryLab 2.0, you are able to enter incomplete runs and still get a good DryLab model. For example, say you have a sample with four peaks you are interested in. You do one experiment at 40%B and another at 60%B, but only two of the peaks are resolved at each of these conditions. You then do experiments at 50%B and 70%B, but at these conditions only the other two peaks are resolved. With DryLab 2.0 you can enter all four of those runs and get a good DryLab model. You would enter the retention times for the first two peaks at the %B that they were resolved, and the second two peaks at the other %B.

You can turn on and off individual values in data entry:

Use the right mouse button to turn on and off individual values in data entry. This is especially useful when used with the previous feature.

New look and feel:

Most parts of the program have been upgraded for this release. The program looks different, but operates in much the same way. Navigation is done primarily through the use of the tabs on the upper left window. If you have any trouble getting around in the program, please let us know, so that we can a) help b) make it easier for others.

Arguments for Investing in DryLab

DryLab helps develop the best solutions for your daily work. Since many years, important pharmaceutical and chemical companies as well as universities, work with this software to keep their methods on the cutting edge. You should use the possibilties offered by DryLab, too.

Here are the most important arguments for using DryLab in your HPLC/GC-laboratories :

1. Save time in your HPLC/GC-Lab! Learn about the influence of parameters in just a few minutes
instead of days, and have the evaluation finished for your report and printout simultaneously.

Method-Development or Method-Optimization with DryLab can save upto 90% of your development time, thereby saving you considerable amounts of money. The methods developed in DryLab often has as little as 50% of the run time of methods developed by try and error in the lab. This offers you the possibility to double the utilization of your expensive equipment and personal. To run an HPLC/GC equipment costs inbetween 750 and 1400 US $ per day. The experimental work done in one hour in the lab, can be done in less than one minute by using the DryLab software. This time reduction is of uttermost importance to your company, since every single day that your products market introduction is delayed will cost you tenth of thousands US $.

2. By using Drylab you can save materials like columns or toxic eluents:

Eluents like Tetrahydrofuran costs up to $70,- per L and Acetonitril $40,- per L.

3. Unnecessary experiments will be avoided by implementing an intelligent systematization based on modern scientific knowledge, robust computer-modeling and simulation with DryLab:

The pharmaceutical industry uses up to 16 percent of the development cost of a new drug on the development and optimization of HPLC/GC-methods. Since the developed methods often aren't robust, after work on the methods is many times necessary, this causes the costs of HPLC/GC to raise from 16 upto 60 percent of the total development cost of the new drug.

4. With DryLab HPLC/GC-methods can be developed faster and more robust than ever before:

Supported by methods developed and optimized by computer, it is possible to create robust and optimal methods for the validation in just a few minutes.

"I work with difficult samples ... will DryLab help me?"
Drylab includes LC modelling options for gradient conditions, isocratic %B, pH, ternary mobile phases, ionic strenght, additive/buffer concentration, normal phase, temperature, reversed-phase gradient/temperature, as well as temperature program for GC separations. In addition, DryLab's Column Optimization option lets you model changes in column dimensions, particle size, and flow rate. Dwell volume changes and peak tailing can also be modeled to simplify method transfer.

Use the 3-D Resolution Map to Model Two Separation Variables Simultaneously.

"Can I model more than one variable at a time?"

DryLab's 3-D Resolution Map predicts the best mobile phase conditions for modes that model two variables simultaneously. Modeling gradient conditions and temperature, for example, provides excellent selectivity control for complex samples.

"I'm only interested in one degradation product in a complex mixture."

DryLab's Resolution Map shows how resolution changes with separation conditions - for one peak, for several peaks, or for all peaks under evaluation.

"Will a change in separation conditions make my method work again?"

Drylab tells you at a glance by modeling and comparing a separation under a variety of conditions.

Teach new Chromatographers !

Training new staff is time-consuming, and mistakes made at the instrument can be costly. DryLab lets novices do their learning on the computer. As they alter experimental condition, DryLab provides immediate feedback. And, DryLab comes with a Tutorial Guide and built-in examples for self-instruction.

"I need to shorten my run time to get more samples done each day."

 Drylab lets you try out different column configuration and flow rates in seconds.

"How senstitive is my method to small errors in conditions?"

The Robust Resolution Map shows you EXACTLY how rugged your method is. Identify the best conditions to avoid reproducibility problems.

"Import Your Data Files"

DryLab imports data files from nearly any chromatography data system or allows you to customize an import template.

Account for Peak Tailing in Your Modeling

"My separations almost always have tailing peaks"

DryLab models peak tailing to give you a realistic prediction of what your separation will look like when you run your DryLab conditions in the laboratory.

Transfer Gradient Methods from One Instrument to Another

"I need to standardize gradient methods for a variety of instruments in our lab."

DryLab's Gradient Editor predicts the optimum linear gradient for your separation and lets you model multisegmented gradients or adjust methods for different instrument configurations. For exapmle, you can adjust a method for an instrument with a different dwell volume.

Presentation of high Quality Graphics

DryLab is set up for high quality printing at the click of the mouse. DryLab text, graphics and chromatograms can be exported to other programs for custom report generation. Make your method development reports more complete by including the DryLab robustness predictions.

Installation of the DryLab® 2000 Plus

System requirements (recommended)
- Pentium PC
- 64 MB RAM
- Windows 9x, 2000, XP or Windows NT

Installation
1. If you have downloaded the "DryLab2000Plus_Install(3_5_0).exe" file (or similar name) from the internet than open it and continue with step 4

2. If you have got a DryLab® 2000 Plus CD-Rom, insert it into into an available disk drive.
3. From the "DLW 2000 Plus" folder open the "DryLab2000Plus_Install(3_5_0).exe" file (or similar name)
4. Follow the instructions on your computer screen for automated installation.
5. After the installation, a program group "DryLab 2000 Plus" will be installed. Start the evaluation program with a click on the icon "DryLab 2000 Plus" in this group.
6. Please answer the start message on the screen by clicking the button "Read Only". DryLab will be started as a read only module (evaluation program).

Short introduction
This evaluation program makes you aquainted with the advantages and the basic features of the method optimization and development software DryLab®. It runs as a read only module by using example data files. Within the evaluation program you can not save your own data! The example files are located in the ...\DryLab 2000 Plus\Examples directory. They are placed there by the DryLab® installation program. For demonstration purpose you can find several example data files for isocratic, gradient and gas chromatography modes with the file extension *.dlb. After starting DryLab® it will open to the program window titled DryLab® Laboratory with an example data set of. The Laboratory window is the main DryLab® window in which you use the program options to model your separation under different conditions.
To move to the Data Entry window from the Laboratory window, click on the "Data Entry" button. From the Data Entry window, click "Close" to move to the Laboratory window. The "OK"-button does not appear in the evaluation program. So you can not change the data in the Data Entry window.
For more information about working with DryLab® use the help-menu or click F1.

DryLab 2000 Animation