| PeakMatch® |
| For information or support for PeakMatch®, e-mail us or call +49 30 421559-0. According to the Solvophobic Theory, variation of pH, temperature, gradient time, %B or ternary eluent composition makes control of the chromatographic selectivity possible. The identification and assignment of peaks from a set of systematic experiments is an important first step in controlling the HPLC method development process. PeakMatch helps you bring order to your experiments, whether it's separating double peaks, re-arranging turnover peaks, reducing general complexity, zooming into relevant peak areas and deleting irrelevant bands, PeakMatch offers you efficient tools for preparing your peak table in an organized and systematic manner. The simple adjustment of the peak table and the ease of transfer of the data into DryLab® with one mouse-click are key features of PeakMatch. PeakMatch assists your method development efforts in the following four steps: Step 1: Data Organization PeakMatch structures your experiments and handles the documentation, as well as facilitates comparison and recognition of key influences on the method as a whole. The chromatograms and the peak table are displayed completely on one page and in order, which provides a valuable overview of complex data and enhances correct peak assignment.  Click image to zoom Step 2: Peak Tracking Cell colors indicate good (green), questionable (blue), and false (red) peak tracking. A false assignment of the same substance between different experiments is a common reason for mistakes during method modeling. This is why peak matching is so important — it assists the chromatographer in understanding peak movement relative to different experimental conditions. It identifies components from run to run and reports peak data in a single horizontal line. The green color indicates a set of well-tracked peaks.  Click image to zoom Step 3: Data Transfer to DryLab PeakMatch transfers all collected data (peak table with retention times, peak areas, eluents, flow rate, column length, column diameter, particle size, gradient range, etc.) into DryLab with one click of the mouse. Within seconds, DryLab models the separation and generates a large number of virtual experiments. In this way, we reduce trial-and-error laboratory runs to the selection of a small set of number of good experiments.  Click image to zoom Step 4: Validation of the DryLab Model Once you have completed modeling of your separation using DryLab, you use the "Comparison" feature to compare your original experimental runs with the DryLab model. Then, if needed, the Dryab model can be further evaluated and improved.  Click image to zoom The quality of pharmaceutical products is always approved by HPLC methods. A safe and robust method is necessary component of the production process. PeakMatch and DryLab help to achieve this goal by structuring and organizing your work, saving you time and materials, and making the laboratory work more predictable, reliable, transferable, and successful. |
| HPLC Method Development Software |
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