Molnar-Institute for applied chromatography
Home of DryLab Software
HPLC Method Development Software
Copyright 2013
All rights reserved.

For information or support for DryLab, e-mail us or call +49 30 421559-0.

DryLab is the most visual UHPLC/HPLC software available. It collects real data and you can model changes by just a mouseclick. For any change in experimental conditions you get a highly precise chromatogram in just one second.

Learn how DryLab will improve the efficiency and quality of your method development efforts, save you time and money, and enhance your understanding of the chromatographic process.
The DryLab Advantage

Let DryLab handle it for you...

We all know that the "small stuff" is what makes or breaks a chromatography method. The trick is to keep the small stuff under control. DryLab models chromatography variables in seconds, and that power lets you evaluate a much wider range of experimental conditions than would ever be practical in the laboratory. With DryLab, you can quickly determine the effects of pH, temperature, buffer concentration, and more on your separation.

Take a look at just some of the features DryLab has to offer. This systematic approach to computerized method optimization has many advantages:

  • Save Time: DryLab saves you time: 1) when you are optimizing your method: most experiments can be simulated in a matter of seconds, or 2) when you are running your method on a routine basis: the optimization process then allows you to minimize retention times and run time.

  • Simplify Transfer: DryLab eases the transfer of a method from one instrument to another. For example, DryLab data can be e-mailed to different locations. The model then can be applied to other instruments (e.g. with different dwell volumes) without losing quality or the control of the method.

  • Select Effective Variables: DryLab shows you which variables are more sensitive than others and where adjustments can be made to a method without losing quality.

  • Prioritize: DryLab allows your company to choose and prioritize the most important factors (cost efficiency, fast run time, robustness, maximum resolution, minimal use of eluents, etc.) instead of relying on trial-and-error results or outdated methods.

  • Minimize Cost: DryLab helps minimize the consumption and wear of expensive laboratory supplies, such as columns, eluents, and instruments.

  • Train Chemists: DryLab enhances the teaching of chromatography by offering immediate feedback on the effect of changing experimental variables. With DryLab, you can "play" with the separation and learn valuable information that would be impossible with laboratory runs.

With a minimum of experimental effort, DryLab provides you with maximum of information on your method.

DryLab Q&A

I work with difficult samples... will DryLab help me?"

A1: DryLab includes LC modeling options for gradient conditions, isocratic %B, pH, ternary mobile phases, ionic strength, additive/buffer concentration, normal phase, temperature, reversed-phase gradient/temperature, as well as temperature program for GC separations (see figure below). In addition, DryLab's Column Optimization option lets you model changes to column dimensions, particle size, and flow rate. Dwell volume changes and peak tailing can also be modeled to simplify method transfer.

Click image to zoom

Model all relevant variables for LC and GC separations!

Can I model more than one variable at a time?"

A2: DryLab's 3D Resolution Map predicts optimum mobile phase conditions for modes that model 3 measured variables simultaneously and allows the calculation and visualization of the variation of column length, ID, particle size, flow rate, dwell volume, gradient start and end plus up to 10 gradient points at the same time 
(see figure below). Modeling gradient conditions and temperature, for example, provides excellent selectivity control for complex samples. See a demonstration of the new 3D resolution Design Space.

DryLab 3D Resolution Map


image to zoom

Use the Robustness Modul to Model up to 10 Separation Variables Simultaneously

I am only interested in one degradation product in a complex mixture. Will DryLab help?

A3: DryLab's Resolution Map shows how resolution changes with separation conditions for one peak, for several peaks, or for all peaks under evaluation
(see figure below).

DryLab Resolution Map Control
Click image to zoom

Find the Best Conditions for ANY Component in a Complex Mixture

Q4: Will a change in separation conditions make my method work again?

A4: DryLab tells you at a glance by modeling and comparing a separation under a variety of conditions
(see figure below).

DryLab Separation Comparison
Click image to zoom

Troubleshoot Existing Methods

Q5: Can DryLab be applied to training?

A5: Training new staff is time-consuming, and mistakes made at the instrument can be costly. DryLab lets novices do their learning on the computer. As they alter experimental conditions, DryLab provides immediate feedback. And, DryLab comes with a Tutorial Guide and built-in examples for self-instruction.

Teach New Chromatographers

Q6: I need to shorten my run time to get more samples done each day. Is DryLab useful for this?

A6: DryLab lets you try out different column configurations and flow rates in seconds.

Shorten Run Times!

How sensitive is my method to small inaccuracies in conditions?

A7: The DryLab-Robustness Modul shows you how robust your method is and how much Out of Specification (OoS) results you might have 
(see red experiments in figure below). Identify the best conditions to avoid reproducibility problems: Have the best separation immediately.

DryLab 3D Design Space

Evaluate Method Robustness

Q8: How easy is it to enter my data into DryLab?

A8: DryLab imports data files from nearly any chromatography data system or allows you to customize an import template.

Import Your Data Files!

Q9: My separations almost always have tailing peaks.

A9: DryLab models peak tailing to give you a realistic prediction of what your separation will look like when you run your DryLab conditions in the laboratory
(see figure below).

DryLab Peak Tailing Data
Click image to zoom

Account for Peak Tailing in Your Modeling!

Q10: Can DryLab be used to help standardize gradient methods for a variety of intruments in our lab?

A10: DryLab's Gradient Editor predicts the optimum linear gradient for your separation and lets you model multisegmented gradients or adjust methods for different instrument configurations. For example, you can adjust a method for an instrument with a different dwell volume
(see figure below).

DryLab Gradient Editor
Click image to zoom

Transfer Gradient Methods from One Instrument to Another!


30 Aug 2014
ISSS 2014
08 Sep 2014
DryLab & QbD Courses
14 Sep 2014
ISC 2014
17 Nov 2014
EAS 2014
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