| DryLab Brochures, Presentations & Videos |
| Brochures Presentations Videos Exploration of a Three-dimensional Resolution Model Plotting the Influence of the Parameters, i) Temperature (T), ii) Gradient time (tG) and iii) Ternary composition (tC), on the Separation of a Mixture of Pharmaceutical Compounds. The 3D resolution model (The Cube) can be thoroughly examined by looking at successive Temperature vs. Gradient Time planes. In this example the third dimension is the Ternary Eluent composition which changes continuously from 100% Methanol on the front side of the Cube to 100% Acetonitrile in the back. As the cursor moves within a given tG-T resolution plane, the lower chromatogram field instantaneously displays the corresponding separation predicted for a given combination of parameters. As one travels through the Design Space, the extension of the red high-resolution areas into this Cube and the robust working regions they form become more apparent. Visualization of this is made even easier by eliminating the low-resolution areas of the cube, leaving behind only the red volumes representing the most robust working spaces within the model. In this model, the most robust working region corresponds to a high percentage of Acetonitrile in eluent B. Exploration of a Three-dimensional Resolution model Plotting the Influence of the Parameters, i) Temperature (T), ii) Gradient time (tG) and iii) pH, on the Separation of a Mixture of Pharmaceutical Compounds. The 3D resolution model (The Cube) can be thoroughly examined by looking at successive Temperature vs. Gradient Time planes. In this example the third dimension is the eluent pH, which changes continuously from pH 3.2 on the front side of the Cube to pH 2 in the back. As the cursor moves within a given tG-T resolution plane, the lower chromatogram field instantaneously displays the corresponding separation predicted for a given combination of parameters. As one travels through the Design Space, the extension of the red high-resolution areas into this Cube and the robust working regions they form become more apparent. Visualization of this is made even easier by eliminating the low-resolution areas of the cube, leaving behind only the red volumes representing the most robust working spaces within the Cube. In this model, the most robust working region corresponds to a pH of approximately 3. |
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