Molnar-Institute: DryLabÂ® and PeakMatchÂ® Course

DryLab® & PeakMatch® User Courses

Course Overview

Who Should Attend

Course Outline

Instructors

Course Dates

Registration

In-house Courses
Course Overview (PDF)

In this two-day course, you will learn the principles of DryLab® and PeakMatch® software and how separation modeling supports and improves your HPLC work. This course covers the systematic Design of Experiments (DoE) for the development of HPLC methods and how to carry out peak tracking for 4 to 12 experimental HPLC runs and better understand peak movement. You will learn to rejuvenate old methods quickly and improve performance by changing separation conditions within the DryLab "Design Space."

This course also covers techniques for finding the best equivalent column or a replacement column for your separation and how to shorten run times while maintaining the desired selectivity and critical resolution. You will learn how to use special statistical tools to select robust conditions for improved method transfer. Most importantly, you will learn how to approach problematic methods in a logical, systematic manner for improved results.

Who Should Attend

Analytical chemists and members of R&D or quality control groups in the pharmaceutial, chemical, and food industries.

Course Outline

Topics for this course include:

The chromatographic prerequisites for the development of an efficient HPLC-method. How to quickly determine which parameters are most promising to optimize. Why robust methods for the validation process are so important.

How to select suitable input runs for systematic development of HPLC methods. The use of DryLab with different experimental designs. Determining how many input runs are needed by DryLab. Using DryLab to develop more robust methods.

Organization of experimental data and peak tracking using PeakMatch. Correction of peak overlap and reversed elution order. Elimination of non-relevant peaks from the peak table used for separation modeling.

The steps for using DryLab to quickly model a separation. How to evaluate the strengths, weaknesses, and quality of an HPLC-method.

Using DryLab to find optimum conditions for gradient methods and determining how selectivity changes when a method is transferred. Optimizing of column dimensions and flow rate for faster methods.

Evaluating method robustness from a DryLab model. Using the Design Space in HPLC according to the Quality by Design (QbD) principles. Using new 3-dimensional tools to optimize multifactorial HPLC.

Instructors

Dr. Imre Molnár studied chemistry in Saarbrücken with special training in analytical chemistry. He then worked for two years as a postdoctoral fellow with Csaba Horváth at Yale University, USA, on fundamentals of reversed-phase chromatography. He has more than 30 years of experience in the development of HPLC instruments, column production, and HPLC applications and is specialized in pharmaceutical and biopolymer research and analysis. He has served as an HPLC instructor throughout his career. Since 1986, Dr. Molnar worked in close cooperation with Lloyd R. Snyder, John Dolan, Tom Jupille, and co-workers from LC Resources. Inc., USA, on the development of DryLab software.

Dr. Hans-Jürgen Rieger studied chemistry in Berlin. He has worked since 1999 for Molnár Institute as an application chemist with a specialization in software programming. In coorperation with Dr. Molnar, he is responsible for the development of new versions of DryLab and the software tool PeakMatch.

Course Dates

German language:


26-27 March 2012
03-04 September 2012

English language:

07-08 May 2012
05-06 November 2012

Registration

The cost of this course is EUR 1490.00.

To register for courses, please:

Download and complete the Seminar Registration PDF, and fax it to us at +49 30 421559-99 - or -

Contact us directly by telephone or e-mail. Indicate the number of interested participants, and we will send you a price quote and a confirmation of the date.

For registration six weeks in advance of the course date, the cost is discounted. DryLab users may qualify for a special reduced fee. Please contact us for details.

If you would like to arrange an in-house course, let us know the topics you are interested in and suggest dates when the course would be convenient for your group. Contact us.

The cost of the two-day course is EUR 1.490. For registration six weeks in advance of the course date, the cost is discounted to EUR 1.340. DryLab users may qualify for a special reduced fee. Please contact us for details.

In-house Courses

Please note that this course, or a customized version of this course, can be taught in-house at your facility. Please contact us to make arrangements for in-house instruction.

News